Early Relapse Multiple Myeloma The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy . Phase 1 Study of Tasquinimod Alone and in Combination With Standard Therapy for Relapsed or Refractory Myeloma

In August, the first patient was dosed in the phase 1b/2a clinical study of tasquinimod for treatment of relapsed or refractory multiple myeloma. The study, which

Tasquinimod, an oral immunomodulator, is in clinical development for treatment of multiple myeloma, NCT04405167. Laquinimod, an immunomodulator, is evaluated as a potential treatment of the eye Tasquinimod (ABR-215050, Active Biotech/IPSEN) is a quinoline-3-carboxamide derivative that binds to S100A9 and blocks its interaction with receptors TLR4, RAGE, and CD147. Here we investigated whether pharmacological inhibition of S100A9 with tasquinimod inhibits MM progression. Tasquinimod is an experimental therapeutic agent with anti-angiogenic and immunomodulatory properties. Designed to be orally active, the experimental medication has shown potential as a treatment for multiple myeloma in early disease models. It has previously been investigated as a treatment for solid tumors, such as prostate cancer. This study is the first study of tasquinimod, an inhibitor of S100A9, in patients with multiple myeloma.

Tasquinimod's mechanism of action is broadly applicable as anti-tumor treatment and very good results have been achieved in models for multiple myeloma, a blood cancer with a high medical need. Active Biotech is seeking a partner for the continued development of tasquinimod in multiple myeloma. Active Biotech AB (publ) Idag är tasquinimod under utveckling för behandling av multipelt myelom, en ovanlig fo rm av blodcancer med ett stort medicinskt behov. Omfattande prekliniska studier, utförda isamarbete med Wistar Institute i Philadelphia, under de senaste åren ger ett tydligt stöd för att gå vidare med tasquinimod inom multipelt myelom. Ett akademiskt tasquinimod in multiple myeloma. Preclinical data from experimental models of multiple myeloma demonstrating effect of tasquinimod as a monotherapy and in combination with standard multiple myeloma treatment, were presented at the Virtual Edition of the 25th European Hematology Association Annual Congress Meeting, in June 2020.

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In a clinical study, SARCLISA given with Pomalyst® (pomalidomide) and dexamethasone (Pd) extended the time people lived without their multiple myeloma getting worse compared to Pd alone (median of 11.5 months vs 6.5 months). Tasquinimod – en potentiell ny produktklass för behandling av multipelt myelom Den kliniska fas Ib/IIa-studien i återkommande refraktärt multipelt myelom pågår vid Abramson Cancer Center i Philadelphia, USA. Studien utvärderar två behandlingsregimer: tasquinimod som monoterapi For both single agent tasquinimod and the combination of tasquinimod and IRd, exploratory expansion cohorts will be enrolled to characterize the anti-myeloma activity of each regimen. Active Biotech announces first patient dosed in phase 1b/2a study of tasquinimod use in treatment of multiple myeloma, by @nasdaq Tasquinimod har patentskydd för behandling av multipelt myelom till 2035.

This study is the first study of tasquinimod, an inhibitor of S100A9, in patients with multiple myeloma.

Clinical effects and an overall good tolerability have been demonstrated in 1500 patients, representing more than 650 patient-years of exposure to tasquinimod. Today, tasquinimod is in development for treatment of multiple myeloma, a rare form of blood cancer with a high Tasquinimod (TASQ) is an investigational drug that targets MDSCs via the S100A9 protein.

Tasquinimod is developed as a new immunomodulatory This study is the first study of tasquinimod, an inhibitor of S100A9, in patients with multiple myeloma. Tasquinimod has previously been studied as an anti-cancer agent in patients with other cancers, including a phase 3 randomized trial in patients with metastatic prostate cancer that showed an improvement in radiographic progression-free survival.
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Lund 12 April 2017 - Active Biotech AB announces today that Active Biotech has been granted Orphan Drug Designation by the U.S. Food and Drug Administration for its | April 11, 2021 PRESS RELEASE Lund Sweden, February 5, 2020 - Active Biotech (NASDAQ STOCKHOLM: ACTI) announces that the Board of Directors, has approved a new direction for th Lund Sverige, 3 augusti, 2020 - Active Biotech (NASDAQ STOCKHOLM: ACTI) meddelar idag att den första patienten har doserats i fas 1b/2a-studien med tasquinimod March 23 (Reuters) - Active Biotech Ab * Active biotech plans to develop tasquinimod for the treatment of multiple myeloma * Says patent application for the treatment of multiple myeloma with the Going progression free longer means going longer without your Multiple Myeloma getting worse. In a clinical study, SARCLISA given with Pomalyst® (pomalidomide) and dexamethasone (Pd) extended the time people lived without their multiple myeloma getting worse compared to Pd alone (median of 11.5 months vs 6.5 months). Tasquinimod – en potentiell ny produktklass för behandling av multipelt myelom Den kliniska fas Ib/IIa-studien i återkommande refraktärt multipelt myelom pågår vid Abramson Cancer Center i Philadelphia, USA. Studien utvärderar två behandlingsregimer: tasquinimod som monoterapi For both single agent tasquinimod and the combination of tasquinimod and IRd, exploratory expansion cohorts will be enrolled to characterize the anti-myeloma activity of each regimen.

Early Relapse Multiple Myeloma The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy .
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March 23 (Reuters) - Active Biotech Ab * Active biotech plans to develop tasquinimod for the treatment of multiple myeloma * Says patent application for the treatment of multiple myeloma with the

What cancer patients, their families, and caregivers need to know about the coronavirus. Whether you or someone you love has cancer, knowing what to expect can help you cope. From basic in Subscribe to Hematology News A meta-analysis found that using circulating microRNAs had high sensitivity and specificity in the early diagnosis of multiple myeloma.

Idag är tasquinimod under utveckling för behandling av multipelt myelom, en ovanlig fo rm av blodcancer med ett stort medicinskt behov. Omfattande prekliniska studier, utförda isamarbete med Wistar Institute i Philadelphia, under de senaste åren ger ett tydligt stöd för att gå vidare med tasquinimod inom multipelt myelom. Ett akademiskt

Tasquinimod is developed as a new immunomodulatory treatment for multiple myeloma. This trial will establish a maximum tolerated dose and optimal schedule for administration of tasquinimod in patients with multiple myeloma and then investigate the maximum tolerated dose of tasquinimod in combination with a standard myeloma regimen of ixazomib, lenalidomide, and dexamethasone (IRd). The introduction of proteasome inhibitors in to the multiple myeloma healing armamentarium has resulted in a dramatic improvement in scientific outcomes (1C5). Nevertheless, despite these advancements, multiple myeloma cells undoubtedly develop level of resistance to proteasome inhibition Tasquinimod resulting in disease development.

Utvecklingen av tasquinimod har tidigare inriktats mot behandling av prostatacancer men denna utveckling avbröts under 2015 efter att resultat från en klinisk fas 3-studie ej gav önskade resultat. Lund Sweden, August 3, 2020 - Active Biotech (NASDAQ STOCKHOLM: ACTI) today announces that the first patient has been dosed in the phase 1b/2a clinical study of Tasquinimod (ABR-215050, Active Biotech, Lund, Sweden) is an investigational drug that binds the S100A9 protein and inhibits the interactions with its receptors. Tasquinimod utvecklas som en ny immunmodulerande behandling för multipelt myelom.